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  • Writer's picturePadme Grace

Glutathione: Master Antioxidant

Glutathione is a powerful antioxidant that plays several crucial roles in the body:

  1. Antioxidant Defense: Glutathione helps neutralize free radicals and reactive oxygen species (ROS), which can damage cells and lead to various diseases such as cancer, cardiovascular disease, and neurodegenerative disorders.

  2. Detoxification: It is involved in the detoxification of harmful substances, including pollutants, heavy metals, and drugs. Glutathione binds to toxins and facilitates their excretion from the body, particularly through the liver.

  3. Immune Function: Glutathione supports the immune system by promoting the proliferation of immune cells and enhancing their ability to fight infections. It also modulates inflammatory responses, helping to regulate immune function.

  4. DNA Synthesis and Repair: Glutathione is essential for the synthesis and repair of DNA, which is crucial for maintaining genetic integrity and preventing mutations that can lead to cancer and other diseases.

  5. Regulation of Cellular Processes: Glutathione regulates various cellular processes, including cell proliferation, apoptosis (programmed cell death), and protein synthesis. It also plays a role in maintaining the balance of redox reactions within cells.

  6. Protection Against Aging: Glutathione levels tend to decline with age, and its antioxidant properties are thought to contribute to longevity and protection against age-related diseases.

  7. Supporting Antioxidant Enzymes: Glutathione helps to recycle other antioxidants such as vitamins C and E, as well as enzymes like catalase and superoxide dismutase (SOD), enhancing their effectiveness in combating oxidative stress.

Overall, glutathione is essential for maintaining overall health and well-being, and deficiencies in glutathione have been associated with various health conditions, including autoimmune diseases, neurodegenerative disorders, and chronic inflammatory conditions.


There are several ways to supplement glutathione levels in the body:

  1. Oral Supplements: Glutathione is available in oral supplement form, typically as capsules or tablets. However, there is some debate about the effectiveness of oral supplementation, as glutathione may be broken down in the digestive tract before it can be absorbed into the bloodstream.

  2. Sublingual Supplements: Some glutathione supplements come in sublingual form, which means they are placed under the tongue for absorption. This route may bypass the digestive system and allow for better absorption directly into the bloodstream.

  3. Liposomal Glutathione: Liposomal formulations encapsulate glutathione molecules in liposomes, which are small lipid vesicles. This encapsulation may protect the glutathione from degradation in the digestive system and improve its absorption.

  4. Intravenous (IV) Therapy: Glutathione can be administered intravenously by a healthcare professional. IV therapy delivers glutathione directly into the bloodstream, bypassing the digestive system and ensuring high bioavailability. This method is often used in medical settings for conditions such as liver disease or as a treatment for certain types of poisoning.

  5. Precursor Supplements: Instead of directly supplementing with glutathione, some people choose to take supplements that contain precursors to glutathione synthesis, such as N-acetylcysteine (NAC), alpha-lipoic acid, or glycine. These compounds can help support the body's natural production of glutathione.

  6. Dietary Sources: Consuming foods rich in sulfur-containing amino acids, such as cysteine, methionine, and glycine, can help support glutathione synthesis in the body. Foods like garlic, onions, cruciferous vegetables (e.g., broccoli, Brussels sprouts), eggs, and lean meats can provide these amino acids.

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